PGD Testing Services
Our comprehensive screening examines all 24 chromosomes (1-22, X and Y) using sensitive chromosomal microarray (CMA) technology. Loss and/or gain of one or more chromosomes (aneuploidy) is common in embryos and can result in IVF failure and other poor reproductive outcomes. When embryos with normal screening results are transferred, the chances of a pregnancy are increased and the risks for miscarriage are reduced.
When a member of a couple carries a balanced translocation (exchange of chromosomal material between two or more chromosomes), a Robertsonian translocation (the joining of two chromosomes) or other structural chromosome rearrangement, their embryos are more likely to have an unbalanced chromosome complement. These abnormalities frequently cause birth defects, mental retardation, and/or miscarriage. PGD for structural chromosome rearrangements identifies embryos that have normal or balanced chromosomes. This allows couples to decrease risks and increase the chance of a healthy ongoing pregnancy. Please contact the laboratory to discuss the specific chromosome rearrangement details before undertaking this type of PGD cycle.
Single Gene Disorders
Inherited disorders such as Huntington disease, spinal muscular atrophy (SMA), cystic fibrosis (CF), and fragile-X syndrome can be devastating to the families they affect. For couples that are at risk to have children with such diseases, GIVF can provide specialized PGD services. Due to the complexity of genetic testing for these disorders, patients should have a full consultation with a medical geneticist to determine if this option would fit their family's needs. Prior to the PGD cycle, the laboratory must be notified in order to develop a patient-specific test for each disorder. In addition to testing for the inherited disorder, aneuploidy screening can also be performed on the same sample.